U.S. doctors online nowAsk doctors free
Magee, MS
A 28-year-old male asked:

How long will diflucan (fluconazole) stay in my body affecting valium dosing? i'm extremely tired while taking both together.

2 doctor answers2 doctors weighed in
Dr. Martin Raff
Infectious Disease 57 years experience
Fluconazole/diazepam: Fluconazole considerably increases exposure to diazepam. Recurrent administration of diazepam increases the risk of clinically significant interactions during fluconazole treatment, because the elimination of diazepam is impaired significantly. The plasma half-life of fluconazole is approximately 30 hours, and reducing the plasma levels will take 5-6 half-lives. This means 180 hrs or about 7+ days
Dr. Anthony Fritz
Internal Medicine 34 years experience
3 days: The half life of diflucan (fluconazole) is 30 hours so after a couple of half lives the affect on other medicine should be fading.
Dr. Martin Raff
Dr. Martin Raff commented
Infectious Disease 57 years experience
It takes about 5-6 half-lives to remove a drug from the circulation.
Dec 9, 2014
Last updated Jul 27, 2021


Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.