I have a vibration happening on the bottom of my left big toe it's weird and has been going on and off for hours?

Toe vibration: Are you diabetic? or have autoimmune disease? In both conditions there can be vascular compromise of the nerves especially at the ends of our body leading to neuropathy, or vascular condition, rarely it could be a sign of MS or it may just be rare fasiculations of unclear cause, would check potassium, magnesium, calcium, glucose,sed rate and thyroid function. Follow up with doctor urgent care.