A member asked:

My ana was positive and my vitamin d count is 14, do those results always mean lupus?

13 doctors weighed in across 6 answers
Dr. Matt Wachsman answered

Specializes in Internal Medicine

No: first, it's the titer and the pattern of the "ANA" which is whether blood is sticky to a slide with cells on it (it IS!!!). If the serum binds when diluted a thousandfold or if it only binds some DNA and not just everything, that would be suspicious. Vitamin D levels are not an indicator of lupus.

Answered 12/1/2014

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Dr. Silviu Pasniciuc answered

Specializes in Internal Medicine

No: Lupus is diagnosed on a constellation of clinical symptoms and diagnostic data. An isolated positive ANA is not enough to make the diagnosis. You definitely have vitamin D deficiency and will need supplemental Vitamin D.

Answered 12/1/2014

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ANA: can only be interpreted within clinical context - furthemore there are varying levels of ANA, not all of them are significant. Only a highly trained physician can properly diagnose lupus. Your Vitamin D levels are low but this is not associated with SLE.

Answered 12/1/2014

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Dr. Roy Arnold answered

Specializes in Internal Medicine

No: There are many causes for a positive ANA besides Lupus. Vitamin D deficiency and Lupus have no connection. Revisit your doctor and discuss these results. Thanks for trusting HealthTap!

Answered 12/26/2017

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Dr. Joram Seggev answered

Specializes in Internal Medicine - Allergy & Immunology

Need more info: ANA (anti-nuclear antibody) may suggest sLE if high titer, usually a dilution of 1:320 or higher plus appropriate symptoms and other tests such as an elevated erythrocyte sedimentation rate (ESR). Low titers of ANA occur in 10% of normal females, even higher over age 60 without any disease. The lowest normal level of vitamin D is 30 and is not a test involved in the diagnosis of sLE.

Answered 12/26/2017

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No: The ANA test is sensitive but not specific. Therefore the test has a high false positive rate. In other words, the test is designed to identify possible problems but is not specific for any disease. I would advise that you see a rheumatologist so you can have further testing to determine whether you do have a collagen vascular disorder. I would also suggest that you treat your vitamin D deficiency aggressively as it's been shown to have an effect on your immune status.

Answered 12/26/2017

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