How many vicodin can you take in one night without overdosing?

Acetaminophen: The real issue is the amount of Acetaminophen you take. Textbooks claim a maximum daily dose of 4000 mg. I have seen liver damage done with far less. I would suggest you keep the Acetaminophen intake to no more than 2500 mg. 5 mg vicodin has 5oo mg of Acetaminophen pertablet, vicodin es has 750 mg and vicoden hp (10 mg) has 660 mg.