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A member asked:
What causes ductal carcinoma in situ (dcis)?
A doctor has provided 1 answer
Viral insertion: DCIS is the earliest phase of transformation to malignancy developing in the ductal system before invasion into parenchyma has occurred. It is defined on mammo by clustered microcalcification. In general the long terminal repeat of the MMTV viral genome enters the ductal cell to initiate transformation. with time the cells become aggressive and invade basement membrane helped by the EBV virus
Answered 2/24/2018
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