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A member asked:
Does prozac (fluoxetine) increase glutamate or reduce it?
A doctor has provided 1 answer
Neither: By reducing the rate of serotonin removal (norepinephrin in SNRIs) SSRIs alter the relative balance of those neurotransmitters w/ glutamate (G) but that's an indirect increase. Since high (G) seems associated w/ depression - they might unintentionally make things worse for some folk (paradox side effect). An experimental new drug (riluzole) to > G is being studied now. Who knows?
Answered 9/28/2016
3.6k views
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