Pms - before it starts i get so depressed, so teary and want to die. im no good for a few days. unhappy. already on pristiq (desvenlafaxine) and epo. please help?

Psychiatrist: Please consult with a capable psychiatrist. It is not uncommon for the first anti-depressant to not be successful. 6-8 weeks is considered a adequate trial but adjustments prior to that time period may be made.

Go to the ER: If you are feeling suicidal calling 911 to transfer you to the hospital is key. Sometimes hormones are responsible for feeling this way but I am very concerned on what you wrote. Please call 911 or go to the emergency room so we can better help you.