Is sam-e better than st.johns wort, or can i take them both at the same time?

See a doc: If you are so depressed that you are thinking of this, or mixing it with St. John's wort, you are much better off getting a med whose dosage is known, its production for potency per mg is regulated, & whose side effects are well studied and understood. If you do not wish to see a doctor, consider non-medical ways to treat depression which are known to help. Proper diet, regular exercise, therapy