A member asked:

What is the difference between prednisone and methlprednisolone? what are the most common affects they have over time. i'm on methlprednisolone.

7 doctors weighed in across 2 answers

Pred v methylpred: These are virtually the same. Methylpred is about 20% more potent than pred. Side effects are same: wt gain, adipose growth, elevate glucose, osteoporosis, cataract, elevate bp, salt retention, infection potentiation, muscle weakness, sleeplessness, and psych ups and downs. These all are dose related. Methylpred can be given IV or PO.

Answered 10/24/2014

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Similar n different: The difference between prednisone and prednisolone is that one is the precursor to the other. Prednisone is activated by enzymes in the liver to turn into prednisolone. They do have similar uses but prednisolone is more readily absorbed by the body. Prednisolone is usually used when there is liver toxicity or liver failure involved.

Answered 11/2/2014

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