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A 40-year-old male asked:

what's the signifigance of finding 53% of peripheral blood cd4+ / cd30+ dual positive cells in a cutaneous lymphoma panel? is this a sign of alcl?

2 doctor answers2 doctors weighed in
Dr. David Masiello
Hematology and Oncology 18 years experience
Possibly: A diagnosis of lymphoma can not be made on flow cytometry alone. This could certainly represent ALK+ lymhoma or other lymphoma a histopathologic diagnosis is required etiher with a bone marrow biopsy, a lymph node biopsy
Dr. Hernani Cualing
Pathology 30 years experience
Could be call MD Onc: The most common Cutaneous T cell lymphoma is mycosis fungoides, which are CD4+ but lacks CD30 early on. Once progressed, the CD4 may acquire CD30, and hence transform to a mimic of anaplastic large CD30 + lymphoma.That said, so is coexpression of 53% in blood is unusual for cutaneous CD30 lymphomas, which are CD4+CD30+ yet mostly confined in skin. Systemic forms may show in blood. Call HemeOnc MD

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Last updated Jul 26, 2015
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