Yes, dangerous: Hi. Non-selective beta-blockers (e.g., propranolol) block beta-2 receptors, which mediate arterial relaxation. Pheos secrete epi and norepi, which activate alpha-1 and beta receptors. If you block vasodilatory beta-2's, then the arteries will see unopposed alpha-1 stimulation, which can cause a hypertensive crisis and stroke, death, etc. Block alpha-1 receptors first!
Answered 10/8/2014
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