How should i use expigment cream for treatment of freckles ??? can i use it once before sleeping??

Don't like freckles?: Test for sensitivity before using by applying a small amount to an area of darker skin and waiting 24 hours. If no reaction,apply a thin film to clean, dry skin twice a day, taking care to not apply to unaffected areas. Wash hands after use. Use sunscreen and, do not use other bleaching agents. Stop if any redness, rash, crusting or swelling and call your doctor. Keep away from eyes, mouth etcHydroquinone works by decreasing the production and increasing the breakdown of melanosomes (melanin pigment granules) in the skin's pigment cells (melanocytes). It does this by inhibiting the activity of tyrosinase, the enzyme needed to make melanin.