Can i take cyclobenzaprine (flexeril) while on paxil (paroxetine)?

Yes but: I would limit use of Flexeril to 1 week as chronic use can cause depression. This is what I was taught at USA medical center in Mobile. This is also what I have seen in 22 years of practice. Robaxin, Norflex (orphenadrine) and Skellaxin are less likely to cause depression.

You can but: It's possible that using the two medications together will increase your body's level of serotonin - one of the body's neurotransmitters. So be on the lookout for agitation, sweats, diarrhea, racing heart, headaches and/or muscle twitching, as these can be signs of too much serotonin in the body.