Could prolonged stay under the sun or a long term exposure to an excessive environmental heat affect the people with mthfr polymorphism? thank you.

MTHFR polymoprhism: It appears in some variants of MTHFR there is an increased risk of skin cancer, but there is no significant literature that MTHFR polymoprphism is associated with heat intolerance . Rare cases of increased hemolysis ot red blood cells in patients who had abnormal red blood and were B12 deficient and that was in a lab experiment not exposure to environmental heat. .