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A 35-year-old male asked:

Is amitriptyline good for idiopathic nerve pain in legs ?

1 doctor answer2 doctors weighed in
Dr. Mark Fisher
Neurology 31 years experience
Yes, but...: Zoloft (sertraline), (sertraline) tramadol and amitriptyline all increase serotonin levels. Amitriptyline also potentiates this effect of Zoloft (sertraline). BTW, Zoloft (sertraline) decreases the effect of tramadol by affecting hepatic metabolism. Gabapentin has no drug interactions at all. Adding amitriptyline at LOW doses may help, with CLOSE monitoring. Read up on serotonin syndrome. It's rare and usu. not life-threatening but be aware of it.
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Last updated May 22, 2016


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