U.S. doctors online nowAsk doctors free
United Kingdom
A 35-year-old male asked:

is amitriptyline good for idiopathic nerve pain in legs ?

1 doctor answer2 doctors weighed in
Dr. Mark Fisher
Neurology 34 years experience
Yes, but...: Zoloft (sertraline), (sertraline) tramadol and amitriptyline all increase serotonin levels. Amitriptyline also potentiates this effect of Zoloft (sertraline). BTW, Zoloft (sertraline) decreases the effect of tramadol by affecting hepatic metabolism. Gabapentin has no drug interactions at all. Adding amitriptyline at LOW doses may help, with CLOSE monitoring. Read up on serotonin syndrome. It's rare and usu. not life-threatening but be aware of it.

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
$30 per visit with
membership

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
$30 per visit with
membership
Last updated May 22, 2016

Disclaimer:

Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.