United Kingdom

A 35-year-old male asked:

Is amitriptyline good for idiopathic nerve pain in legs ?

1 doctor answer • 2 doctors weighed in

Dr. Mark Fisheranswered

Neurology 35 years experience

Yes, but...: Zoloft (sertraline), (sertraline) tramadol and amitriptyline all increase serotonin levels. Amitriptyline also potentiates this effect of Zoloft (sertraline). BTW, Zoloft (sertraline) decreases the effect of tramadol by affecting hepatic metabolism. Gabapentin has no drug interactions at all. Adding amitriptyline at LOW doses may help, with CLOSE monitoring. Read up on serotonin syndrome. It's rare and usu. not life-threatening but be aware of it.

3.7k viewsReviewed >2 years ago

Dr. Evan Altman

Dr. Evan Altman agrees1 doctor agrees

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Can amitriptyline actually cause burning pain in feet and legs. Taking it to reduce that symptom ?

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Last updated May 22, 2016

Found in:

Nerve›Pain›Neuralgia

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