A member asked:

M58, does metformin effect liver and is it necessary to monitor lft while taking metformin. ?

8 doctors weighed in across 3 answers

Yes and no: Hi. Yes, metformin affects the liver. It makes the liver more sensitive to insulin and reduces the release of glucose from the liver. No, you do not need to monitor LFTs while taking metformin. Eat a healthy diet and exercise regularly. Good luck with your diabetes control!

Answered 9/4/2014

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Dr. Thomas Namey answered

Specializes in Rheumatology

Metformin: very rarely adversely affects the liver!

Answered 11/27/2017

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No: metformin is metabolized by the kidneys and typically doesn't have a negative effect on the liver. it is not routine practice to monitor LFT for patients on metformin

Answered 7/16/2018

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