Can lyme disease make you feel crazy and on edge?

Yes: Lyme disease can cause virtually any symptom including many neuropsychiatric symptoms. See http://www.lymeinfo.net/neuropsych.html However, many with Lyme have co-infections with Bartonella which even more commonly makes people feel crazy and on edge. It is important to find a doctor knowledgeable in treating Lyme & co-infections with a holistic approach, as antibiotics seldom help chronic Lyme.