Does smoking effect levaquin (levofloxacin)?

Indirectly: Smoking affects the respiratory tract: inflammation, paralysis of hair-cells that help sweep mucus, etc out of the lungs. So smoking counters/slows the efforts of any antibiotic you're taking for respiratory infection. Like taking a poison & its antidote at the same time.

Not that I know of: Tobacco smoke can cause induction of certain liver enzymes that may hasten their metabolism, but Levofloxacin does not appear to be on the list. However, if you have an infection of any kind, any tobacco product will cause vasoconstriction and reduction of blood flow which may impair ultimate healing. Stopping smoking is in your best interest no matter what drug interactions there may be.Get help.