Can i take levaquin (levofloxacin) and methadone?

Moderate interaction: If taken together, these meds will interact. There have been cardio side effects documented. Depending on the dose of each that you are taking it can even be dangerous. Definitely check with your provider and let them know your exact dosage of all meds.

Not advisable: Generally speaking Methadone by itself carries a risk of causing or worsening an electrical disturbance in the heart (meaning it can affect the rhythm and rate of heartbeat). This effect may lead to increased risk of a condition briefly referred to as Torsade which can potentially cause a fatal irregularity in the heart without any warning. This effect can be amplified by taking Levaquin (levofloxacin) with it.