Can you take cyclobenzeprine with ambien (zolpidem)?

Yes: But not recommended as they may potentiate the effects. So be careful

Caution: It will cause additive central nervous system depression and psychomotor impairment which means you definitely should not drive while taking both medications. If you have any pulmonary conditions like sleep apnea, definitely not. These patients can stop breathing with sedatives and die. How about using ambien (zolpidem) to sleep and save flexeril for daytime use?

Flexeril/Ambien: Some added sedation, otherwise ok.