How many hours can i repeat my dose of butorphanol after my second dose? (nasal spray)

After several hours: Most doctors recommend you use only one spray initially (after proper instruction on how to use/spray). If pain persists after 60-90 minutes, second spray in other nostril can be used. After that do not repeat sooner than 3-4 hours. Some people will need two sprays (one in each nostril) for pain relief but side effects/drowsiness are greater. Follow doctor's directions carefully.

Review with your doc: You should review the dosing regimen that is optimal for you, as this is a plan that should be determined between a patient and his/her physician. Often butorphanol intranasal spray is administered a 1 mg(1 spray) every 3-4 hours as needed but this may not be best for you depending on your pain and medical/medication history.