Just started zoloft (sertraline) - anger for no reason and increased anxiety? initial side effects?

Watch carefully!: While it is possible that those side effects may disappear, it's usually a reason to make a turn-about and find other approaches to your depressive symptoms - including psychotherapy. These are not uncommon and in young men, they may be especially worrying. Definitely tell your provider and ask for alternatives to consider - especially if it doesn't change very, very soon.