Concerning sign: Any headache that is new and persistent, especially when one-sided, and it does not respond to over-the-counter pain relievers, is worth a closer look. The fact that you have had them a year and are still around to talk about is reassuring though. It would be a good idea to get an examination from your primary care provider who can decide what steps should be taken next if no cause is evident.
Answered 8/5/2014
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