No: The CCP can be positive even if the RF is negative.
Answered 2/29/2016
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Yes: Rheumatoid factor and anti-CCP antibodies are commonly found in patients with rheumatoid arthritis (RA). If a patient with RA has +RF and +CCP, it indicates they will likely have a more aggressive disease. Usually, both RF and CCP are positive in RA. It is RARE to have CCP positive without +RF.
Answered 8/4/2014
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