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A 28-year-old female asked:

Tested positive on igg elisa for hsv2. then tested negative on western blot 2 years after last encounter. which test to believe ?

1 doctor answer1 doctor weighed in
Dr. Carrie Cannon
A Verified Doctoranswered
Family Medicine 34 years experience
Western blot: The ELISA screening test is sensitive with a smaller number of false negatives which makes a good screening test. That way fewer true positives are missed. The Western Blot is more specific meaning a smaller number of false positives. A specific test misses few true negatives. It is done for confirmation. You can always repeat the tests in case of specimen mix-up (which I have seen happen before.
Last updated Oct 12, 2014

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