Can i take cefuroxime axetil if allergic to penicillin?

Maybe: You have about a 2-5% chance to also be allergic to cefuroxime. You may want to talk to your allergist about testing to penicillin first to confirm this allergy. If you do have pcn allergy, then you can: 1.Use a different antibiotic 2. Do a graded challenge/desensitization to cefuroxime. If negative to pcn on testing, <1% will have problems with cefuroxime.