A member asked:

Is it possible for aldosterone to make urine hypoosmiotic and concentrated?

A doctor has provided 1 answer

Physiology: Hi. Aldosterone is primarily there to regulate renal handling of sodium, potassium, and acid. Urine concentration/osmolality is more a function of anti-diuretic hormone (ADH) regulating tubular luminal (phenobarbital) water channels and the ambient solute gradient in the loop of Henle. Water follows sodium in general, but the kidneys place quite a degree of regulation on this, so aldo has trivial effect on conc.

Answered 7/6/2014

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