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A member asked:
Why neostigmine is not a drug for treatment of alzheimer's disease?
9 doctors weighed in across 2 answers
Doesn't get in brain: Neostigmine's chemical structure (quaternary amine) does not allow it to cross the blood brain barrier, so it does not affect cholinesterases in the brain.
Answered 11/6/2018
5.8k views
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Would make it worse: Neostigmine is blocking effect of acetylcholine and would probably make the cognitive deficit in alzheimer§s disease worse.
Answered 11/6/2018
5.3k views
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