What are the signs and symptoms of multiple myeloma?

CRAB +: C - hypercalcemia r - renal (kidney) disease, elevated crt a - anemia (not explained by other causes) b - bone disease - eg osteoporosis, fractures, or lytic (moth eat) lesions + neuropathy, frequent infections, etc...

Fatigue, bone pain: To name a couple. Profound anemia and make you fatigued and the cancer growing in your bones can be painful. Patients can get very drowsy from kidney failure, have bone fractures and repeated infections. Sometimes early myeloma is picked up on routine blood or urine tests.

Varied: Some people with multiple myeloma may not have symptoms but common symptoms are back pain, bone pain, fatigue, nausea or vomiting.