A member asked:

Doctors, what are the symptoms of smoulding multiple myeloma?

7 doctors weighed in across 2 answers

Asymptomatic: Smoldering myeloma is a stage of Myeloma before patients become symptomatic. So it is discovered on routine checking of blood proteins or show up in a serum protein electrophoresis(SEP). Many of these patients develop symptoms within one or two years and the symptoms are bone/back pain or a broken bone due to myeloma.

Answered 10/11/2014

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Dr. Michael Thompson answered

Specializes in Hematology and Oncology

Asymptomatic MM: By definition smoldering multiple myeloma (SMM) has meets the definition of MM but without the CRAB symptoms - hyperCalcemia, Renal insufficiency / kidney failure, Anemia, or Bone lesions. SMM is also called "asymptomatic" MM. The standard of care is observation. A clinical trial is evaluating observation vs. treatment with lenalidomide (Revlimid) - ow.ly/oSUig. A SMM article: ow.ly/sZ8zz

Answered 10/11/2014

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