RNP not specific : RNP's are antibodies which may be seen in "overlap" connective tissue disorders and are not as helpful as are other antibody tests when looking for a specific disorder. dsDNS/Sm ab, when present, usually point to the specific diagnosis of Lupus. However, it is just as important to look at all of the information obtained from a person's history and exam to put these tests into a proper context.
Answered 7/15/2015
4.1k views
More specific: Low-titer RNP's may be found in healthy folks, but anti-Sm and anti-dsDNA at titers above the lab's cutoffs are fairly specific for lupus. The diagnosis and decision to treat are ultimately based on the whole clinical picture.
Answered 7/15/2015
2.5k views
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