Heart burn after too much pizza?

Heartburn: Yes, lot of spicy and lot of fat. Heartburn sooner or later.

Yeah....ok....: Occurs, but for a huge number of reasons. The bulk from a lot of food pushing the stomach contents up throat (reflux) or stomach into the chest (hiatal hernia) is pretty common. Ulcers as cause pretty uncommon. Just indigestion w/out clear cause is the most common situation (about 30% of people get this; proton pump inhibitor meds work on all of these) en.wikipedia.org/wiki/Proton-pump_inhibitor

Heartburn.: The tomato sauce in a pizza can trigger reflux/GERD/heartburn. So can spicy pepperoni, fresh tomatoes and simply eating too much pizza too late at night before going to bed.