Will vyvanse (lisdexamfetamine) 30mg affect a drug test after one dose?

It will for 2 days: Average half-life is about 8 hours. It takes approximately 6 half lives for a drug to be eliminated from your system. 8*6/24=2 days. The vyvanse (lisdexamfetamine) will stay in your system for 2 days. Amphetamine-type medications can be habit-forming.

Yes, depending on : When testing is done relative to when it was taken. However, "drug screens" are read as positive by the concentration of a drug or its metabolite in the urine sample; therefore, depending on timing, the concentration may fall below the cut-off point for a "positive" screen. It isn't a problem for anyone who can show a prescription bottle in his or her name. Diversion is a different story.

Depends: It depends on when you have the test after you take the Vyvanse (lisdexamfetamine)