That depends on how: Long you were on Methadone and on what dose. Suboxone (buprenorphine) will precipitate withdrawal in people who are dependent on other opioid drugs. Methadone is very long-acting, and precipitated withdrawal can occur even days after your last dose if you were on Methadone long-term. Tapering Methadone down to 30 mg or less, and waiting 2-3 days (until withdrawal is present) is safest way.
Answered 8/13/2018
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