A 46-year-old member asked:
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what can occur if you take methadone while being on suboxone?

3 doctor answers
Dr. Philip Gilly
38 years experience Addiction Medicine
Glad you asked ...: Suboxone attaches to the same opioid receptors in the brain as does methadone, but sub binds much more strongly than mtd does. Therefore, if your brain is full of sub and you take mtd, you will notice very little effect. However, if you take the mtd first and the sub second, the mtd will be replaced by the sub and you will go into precipitated withdrawal, likely quite severe. Don't mix the two.
Answered on Jun 20, 2015
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Dr. Dheeraj Raina
28 years experience Psychiatry
May not work: Suboxone may cause methdone not not work.
Answered on Oct 27, 2020
Dr. Cyma Khalily
34 years experience Psychiatry
HOPEFULLY NOTHING: Obviously you realize that this should not be done and defeats the whole purpose of the Suboxone. There is an opiate blocker but I would not recommend ever doing this.
Answered on Apr 7, 2020

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Dr. Ernest Leibov
52 years experience Psychiatry
No!!!: It could lead to respiratory arresr!
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A 45-year-old member asked:
Dr. Alan Wartenberg
A Verified Doctor answered
A US doctor answered Learn more
That depends on how: Long you were on Methadone and on what dose. Suboxone (buprenorphine) will precipitate withdrawal in people who are dependent on other opioid drugs. M ... Read More
A 33-year-old male asked:
Dr. Paul Pyles
32 years experience Addiction Medicine
24 Hours: Methadone has a long half-life. You should wait at least 24 hours before taking Suboxone. See your doctor about your sleep.
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A male asked:
Dr. John Gaffney
24 years experience Psychiatry
Probably not: Why are you taking Suboxone and methadone? They're very rarely used together. The problem with methadone is that the bioavailability & half-life ... Read More

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