A member asked:

Hello, i'm interested what are chances of me getting als? my grandfather died of als after fighting disease for 8 years.. no one in my family had als

4 doctors weighed in across 2 answers

ALS: Als or amyotrophic lateral sclerosis is a neurodegenerative disease that attacks the upper and lower motor neurons. There is no known cause and no known cure. Fortunately, only 10% of all ALS cases have a family history. The cases are transmitted in an autosomal dominant fashion and the defect is on chromosome 21.

Answered 11/10/2015

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Very remote chance: ALS thankfully is a rare disease. It is very infrequently associated with genetic risk, and based on your description, likely your grandfather had a sporadic case. Thus, the odds of your acquiring the disease is very minimal at most.

Answered 10/24/2015

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