Out of all antipsychotics which is the least likely to cause restlessness and akathisia?

Least likely...: ... Is probably seroquel ( generic name is quetiapine). There are 2 forms, the plain seroquel, which is available now as a generic, and the seroquel xr, the extended -release. They are both good for sleep as well. In addition to being approved for schizophrenia and psychotic disorders, seroquel xr is one of only 2 drugs fda approved for bipolar depression, and it acts as a mood stabilizer as well.