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A 43-year-old member asked:

Can you suggest any alternative methods to treating hodgkin's lymphoma patients who respond negatively to avbd treatment?

3 doctor answers5 doctors weighed in
Dr. Liawaty Ho
Hematology and Oncology 23 years experience
HL: there are other treatments available for refractory Hodgkin's lymphoma - i.e Adcetris/brentuximab vedotin - that is very responsive for hodgkins. other chemo and clinical trials are also available . I would suggest you the above. please discuss with your oncologist re your options. see this : http://clinicaltrial.gov/ct2/results?term=hodgkin+lymphoma&Search=Search
Dr. Matthew Fero
Medical Oncology 31 years experience
Alternative regimens: ...should be tried to achieve a remission if ABVD fails. These typically include carboplatin. If successful, this should be followed by high dose therapy and an autologous stem cell transplant. A new antibody therapy is also helpful (brentuximab) and it too should be followed by stem cell transplant. Finally, radiation therapy can be useful as a supplement if there is a site with bulky disease.
Dr. Ephraim Hochberg
Medical Oncology 25 years experience
Adcetris (brentuximab vedotin) / Nivolumab: There are several classes of drugs that offer good options for patients with Hodgkin lymphoma who have not responded to ABVD. The standard of care in a younger patient is intensive salvage chemotherapy and stem cell transplant. Other options would include Brentuximab or a PD1 inhibitor such as Nivolumab or Pembrolizumab.

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Last updated Jan 25, 2020
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