A 43-year-old member asked:
Can you suggest any alternative methods to treating hodgkin's lymphoma patients who respond negatively to avbd treatment?
3 doctor answers • 5 doctors weighed in
Hematology and Oncology 23 years experience
3.9k viewsAnswered >2 years ago
Medical Oncology 31 years experience
Alternative regimens: ...should be tried to achieve a remission if ABVD fails. These typically include carboplatin. If successful, this should be followed by high dose therapy and an autologous stem cell transplant. A new antibody therapy is also helpful (brentuximab) and it too should be followed by stem cell transplant. Finally, radiation therapy can be useful as a supplement if there is a site with bulky disease.
3.3k viewsReviewed >2 years ago
Medical Oncology 25 years experience
Adcetris (brentuximab vedotin) / Nivolumab: There are several classes of drugs that offer good options for patients with Hodgkin lymphoma who have not responded to ABVD. The standard of care in a younger patient is intensive salvage chemotherapy and stem cell transplant. Other options would include Brentuximab or a PD1 inhibitor such as Nivolumab or Pembrolizumab.
3k viewsReviewed >2 years ago
Last updated Jan 25, 2020
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