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A 21-year-old member asked:

Is lou gehrig's disease dominant or recessive?

2 doctor answers3 doctors weighed in
Dr. Michael Depietro
Pulmonary Critical Care 35 years experience
Neither: 90-90% of case of ALS are not inherited, it occurs at random at its cause is not known. In 5-10% of cases there is a familial form of the disease. In these 5-10% of cases it is usually dominant (meaning it is only necessary to have one copy of the defective gene) remember however most of the time it is not inherited at all.
Dr. Bennett Machanic
Neurology 52 years experience
NEITHER: 90% of all cases are sporadic and not of genetic origin. Maybe 10% of cases can be genetic, some associated with front-temporal dementia, 25% associate with superoxide dismutase. The eventual outcome is similar regardless of the above.

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Last updated Jan 12, 2015
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