Is sickle cell disease dominant or recesive?

Dominant genetically: Sickle cell disease is inherited as an autosomal recessive condition, which is what you will read from online sources and textbooks. One must inherit the gene from both parents to have the disease. This assumes that inheriting one copy of the gene (trait patient) has no phenotype (medical problems). This is not exactly true, as athletes have died from trait under extreme conditions.

Sickle cell disease: Is observed when a patient inherits two copies of the mutant beta globin gene (which harbors a mutation from glutamate to valine at Amino Acid #6), or inherits one copy of the mutant allele in the context of beta thalassemia trait (so-called "sickle-beta thal"). As such, it can be thought of as recessive from a classical mendelian perspective. A normal beta globin ameliorates beta-s neg effects.