A member asked:

What causes red blood cells to sickle?

3 doctors weighed in across 2 answers

Hemoglobin S: A genetic variant of hemoglobin, called hemoglobin s causes sickling when hemoglobin loses oxygen.

Answered 9/18/2012

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Dr. Ruben Mesa answered

Specializes in Hematology

Stress: Sickled red blood cells can arise in individuals with hemoglobin s (those with sickle cell disease typically (of african or middle eastern descent usually). Low oxygen and stress, and dehydration, can all be a factor in sickling.

Answered 9/8/2013

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