HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

Will i respond to 25 mg hydroxyzine in the same way i respond to 25mg diphenhydramine?

A doctor has provided 1 answer
Dr. John Chiu answered

Can't tell: Although they possess similar actions and side effects, no one can predict with certainty how you may react to either.

Answered 3/10/2019

4.2k views

Thank

Related Questions

A member asked:

Cannot take benzo or rx sleep meds, I am prescribed hydroxyzine, I've been told I can take Benadryl (diphenhydramine) w/it if I build tolerance to the hydroxyzine?

A doctor has provided 1 answer

A member asked:

I am taking Benadryl (diphenhydramine) with minimal side effects only light sedation. Going to try hydroxyzine. Will I get more side effects than Benadryl (diphenhydramine)?

2 doctors weighed in across 2 answers

A member asked:

Hives for 4 days I hve perscribed meds hydroxyzine 25mg, diphenhydramine 25 mg, Ranitidine hydrochloride 150 mg & cetirizine 10mg .. Wat should I use?

A doctor has provided 1 answer

A member asked:

Itchy skin for about a year now, have taken Benadryl, (diphenhydramine) Zyrtec, steroid shot from dermatologist and currently on hydroxyzine 25 mg, any help?

A doctor has provided 1 answer

A member asked:

Can I take doxylamine or diphenhydramine for anxiety or should I ask my dr about atarax (hydroxyzine)?

A doctor has provided 1 answer

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

How long after taking hydroxyzine can I take diphenhydramine?
What is the difference between hydroxyzine and diphenhydramine?
Is it safer to take Benadryl (diphenhydramine) or hydroxyzine while taking tramadol 75-100mg?
Is there a difference between diphenhydramine and hydroxyzine for anxiety?
I have two different antihistamines...One is hydroxyzine and the other is is diphenhydramine..Which one will cause me to gain weight?

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.