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A member asked:
My alt/ast enzymes are elevated and i tested positive for mitochondrial m2 ab igg (34.6) antibodies. is this a definitive diagnosis of pbc?
3 doctors weighed in across 2 answers
No: What's the titer? Does this match your symptoms / signs / other labs? Even the big fancy commercial labs make mistakes with these.
Answered 2/3/2015
4.3k views
False +ve AMA <2%: At higher level of AP, PBC can be diagnosed without a liver biopsy provided that the antimitochondrial antibody (AMA) is positive. Patients with high AP and high aspartate aminotransferase (AST) levels should undergo a liver biopsy to diagnose the overlap of autoimmune hepatitis with PBC.Anti-mitochondrial M2 antibodyis specific for PBC, but can also be found in Auto-immune hepatitis.
Answered 4/23/2023
104 views
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