False +ve AMA , <2%: In PBC, approximately 90%-95% of serum samples react against PDC-E2, making this the most important autoantigen in the disease. Anti-M2 is most important subtype used in routine diagnostic tests for PBC. Its level in affected sera is high and it also exists in other body fluids such as saliva and bile. Positive test is potentially diagnostic, or at least indicative that the individual is at RISK
Answered 2/2/2020
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