Is alcohol and smoking on hrt safe?

Smoking NO, alcohol: Maybe, if in limited quantities on occasion. The combination of hormone replacement therapy and cigarette smoking (or any tobacco use) is a formula to get blood clots in the legs, which can cause damage there, or travel to the lungs where they can kill you. Safe drinking for a woman is no more than one drink per day, or 7/week, and never more than 3 on any one occasion. On hrt, once/week is plenty.

Smoking and HRT.: Smoking and HRT are very bad together, greatly increasing the risks of cardiovascular side effects, like blood clots and strokes. Alcohol in large quantities, both primarily and secondarily, can have some estrogenic effects which could impact those also taking HRT, too. Smoking is dangerous enough just by itself.