I recently started taking tikosyn (dofetilide) for afib. can i use an antibiotic cream for an infected toe, or will it interact with the tikosyn (dofetilide)?

Yes: Unlikely to have significant absorption or interference. Good to check, and discuss with your cardiologist for future planning.

Probably not: You are right to ask about interactions between medicines. Tikosyn (dofetilide) is an antiarrhythmic medication with a number of drug-drug interactions. Generally topical antibiotics (applied to the skin surface) do not interact with internal medications however it would be best to know the specific antibiotic to check for a specific interaction.