I use 4 mg amaryl (glimepiride) morn and night, added 100 mg invokana, sugar 150-165 at night, can i increase either drug, 61 yr male, 189 lbs, a runner.

Diabets: Amaryl (glimepiride) and Invokana is a fairly unusual combination to begin with. Amaryl (glimepiride) is at its max of 8 mg daily, whereas Invokana may be increased to 300 mg, but i would not based that decision only upon A.M. Sugar readings. You should also measure a1c, a 3 month average sugar measurement, and also after meal sugars. Metformin is considered first line medication in diabetes. Wonder why it is not on the list.

Yes: Invokana can be increased up to 300mg/day in patients that tolerate the drug. It appears that you are already at the max daily dose of amaryl, (glimepiride) and likely wouldn't add an additional benefit to increase the dose. You should talk with your doctor before increasing any drug.