Can there be complications with mono if i have cancer?

Maybe yes: Although the great majority of normal, healthy people recover from ebv (mono) infection without any long term problems, there are always an unlucky few who have very serious symptoms. A person with cancer and a weakened immune system, or damage to the spleen, liver, blood cells, or bone marrow, may have more complications from ebv. Chronic or recurrent epstein-barr virus infections can also occur.

Infect Mono & Cancer: Infectious mononucleosis (im) is caused by the ebstein-barr virus (ebv). Like with any virus, the delicate balance between recovery and complication depends on your immune status, and cancer can cause immunocompromise. Only your doctor can assess your risk, based on the type of cancer you have, its extent, your general state of health and immune status, and other factors.