Can ana be + (1.160) 2 yrs ago then - now esr varies from 25-40 but normal now ccp 5<5 at the moment aching all over, ache &burning sens in hands ra?

Paradox: The great paradox of the use of labs in rheumatology is that despite the large number that are available, the diagnosis depends more on history and physical exam than in any other specialty. Esr fluctuates from day to day and doing it is full of pitfalls. The low ccp does speak against rheumatoid arthritis, but the real question is, "how to treat?" and that's where labs can't take your dr's place.