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A member asked:

Can you take methotrexate tablets and folic acid tablet at same time?

A doctor has provided 1 answer
Dr. Paul Grin answered

Specializes in Pain Management

Not recommended: Folic acid decreases effects of Methotrexate and the result is creates an opposite drug effect, hence should not be used together. The same applies to nsaids (aspirin) and methotrexate.

Answered 6/28/2014

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I have off the chart high levels of both B12 and folate, with low ferritin. in a blood test. I was told long ago I cannot process folic Acid well. Now I take it with methotrexate. Could this folic be the cause of these results?

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Take propecia 1mg, methotrexate 25mg, arava (leflunomide) 20mg, enbrel weekly, B12 & folic acid..Which ones are most likely to cause high liver enzymes(ast&alt)?

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What is the proper amount of folic acid should be taking to cover a 20 mg of methotrexate?

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If methotrexate works be decreasing folic acid which inhibits cell growth, isn't adding high doses of folic acid defeating the purpose?

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